Augmentation of chimerism with perioperative donor bone marrow infusion in organ transplant recipients: a 44 month follow-up.
نویسندگان
چکیده
'"I IE HAVE previo~y documented the long-term perV V sistence of donor cell chimerism after successful organ transplantation (Tx) and have postulated that it plays a seminal role in allograft acceptance and in the induction and perpetration of donor-specific tolerance.1•2 To further enhance the salutary effects of chimerism we have augmented this phenomenon, since December 1992, by infusing unmodified donor bone marrow (BM) into 190 organ allograft recipients; the unavailability of consent to retrieve vertebral bodies has resulted in accrual of 110 contemporaneous controls. We present here an interim analysis of these patients at their most recent follow up.
منابع مشابه
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عنوان ژورنال:
- Transplantation proceedings
دوره 29 1-2 شماره
صفحات -
تاریخ انتشار 1997